Table-2.
Toxicological studies of e-Cigarette
| Study | Adverse effects | Reference | |
|---|---|---|---|
| 1. | Human embryonic stem cells (hESC), mouse neural stem cells (mNSC), and human pulmonary fibroblasts (hPF) were exposed to e-Cigarette refill liquid. |
Cytotoxicity was observed excluding hPF cells. |
(Bahl et al., 2012) |
| 2. | Human airway epithelial cells (H292) and wild type C57BL/6J mice were exposed to e- Cigarette aerosol. |
Oxidative stress and Inflammatory response. |
(Lerner et al., 2015) |
| 3. | Thirty healthy smoker inhaled e-Cigarette for 5 minutes. |
Fraction of exhaled nitric oxide (FENO) was reduced while total peripheral airway resistance was enhanced. |
(Vardavas et al., 2012) |
| 4. | Fifteen smokers underwent acute e-Cigarette exposure. |
3% reduction in FEV1/FVC | (Flouris et al., 2013) |
| 5. | Long term (6 months) use of e-Cigarette by forty participants. |
Irritation of mouth and throat | (Polosa et al., 2014) |
Reference List
Bahl V, Lin S, Xu N, Davis B, Wang YH, Talbot P (Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models. Reprod Toxicol 34:529–537.2012).
Flouris AD, Chorti MS, Poulianiti KP, Jamurtas AZ, Kostikas K, Tzatzarakis MN, Wallace HA, Tsatsakis AM, Koutedakis Y (Acute impact of active and passive electronic cigarette smoking on serum cotinine and lung function. Inhal Toxicol 25:91–101.2013).
Lerner CA, Sundar IK, Yao H, Gerloff J, Ossip DJ, McIntosh S, Robinson R, Rahman I (Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung. PLoS One 10:e0116732.2015).
Polosa R, Morjaria JB, Caponnetto P, Campagna D, Russo C, Alamo A, Amaradio M, Fisichella A (Effectiveness and tolerability of electronic cigarette in real-life: a 24-month prospective observational study. Intern Emerg Med 9:537–546.2014).
Vardavas CI, Anagnostopoulos N, Kougias M, Evangelopoulou V, Connolly GN, Behrakis PK (Short-term pulmonary effects of using an electronic cigarette: impact on respiratory flow resistance, impedance, and exhaled nitric oxide. Chest 141:1400–1406.2012).