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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: J Orthop Res. 2016 Mar 3;34(11):1950–1959. doi: 10.1002/jor.23209

Figure 6.

Figure 6

To assess the potential of pre-warming of allograft cartilage to decrease stress response and enhance the expression of ECM proteins observed in fresh cartilage, we incubated cartilage specimens from allografts at 37°C and 4°C for 10 days. (a) Evaluation of gene expression using RT-qPCR shows a downregulation in stress response, as well as a decrease in ECM encoding mRNAs. (b) Changes in gene expression are also associated with a decrease in total RNA yields from tissue samples. These findings could be seen with a loss of chondrocyte viability in warmed allograft cartilage.