Table 4.
Pregnancy outcomes during and after MHC
| Pregnancies | Recovery of Sperm Output | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Regimen | n Enrolled | Pregnancies During Treatment (n) | Pregnancy Outcome^ | Pregnancies After Treatment (n) | Pregnancy Outcome^ | Known Pregnancies During and After Treatment (n) | Maximum Treatment Duration (months) | Median time to Recovery 20 M/mL (months) | ||||||||
| LB | SA | IA | UK | CM | LB | SA | IA | UK | CM | |||||||
| a TE 32 | 271 | 10 | 3 | 0 | 6 | 1 | 0 | 10* | 4 | 1 | 2 | 3 | 0 | 20 | 18 | 3.7 |
| b TU 12 | 1045 | 28 | 0 | 0 | 0 | 28 | 0 | Not Reported | - | - | - | - | - | 28 | 30 | 7.6 |
| c T implant 34 | 55 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 3 | 1 | 0 | 1¥ | 5 | 18 | 5.0 | |
| a TE 25 | 399 | 19 | 10 | 4 | 5 | 0 | 0 | 33 | 25 | 1 | 4 | 3 | 0 | 52 | 18 | 2.3 |
| b TU 33 | 308 | 4 | 0 | 0 | 0 | 4 | 0 | 3 | 0 | 0 | 0 | 3 | 0 | 7 | 12 | 2–3 |
| Total (n) | 2078 | 61 | 13 | 4 | 11 | 33 | 0 | 51 | 32 | 3 | 6 | 9 | 1 | 112 | N/A | N/A |
^
LB = live birth; SA = spontaneous abortion; IA = induced abortions; UK = unknown; CM = congenital malformation
a
testosterone enanthate 200 mg/week;
b
testosterone undecanoate 500 mg/month (with 1000 mg loading dose);
c
testosterone implant 800 mg every 4 months with DMAP 300 mg every 3 months
*
Excludes pregnancy by a man other than the partner
¥
Includes one set of twins. One of the twins born with Vater Anomalad, which was thought to be unrelated to the study drug.