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. Author manuscript; available in PMC: 2016 Dec 27.
Published in final edited form as: Biometrics. 2016 Feb 22;72(4):1145–1154. doi: 10.1111/biom.12499

Table 2.

Simulation results on screening performance in ultra-high dimensional cases

SII MB C Index QaSIS (α = 0.25) QaSIS (α = 0.5)

Case n ρ p* ℛ (IQR)
S
ℛ (IQR)
S
ℛ (IQR)
S
ℛ (IQR)
S
ℛ (IQR)
S
I 200 0 4 92.5 (84.75) 0.16 118.5 (86) 0.09 122 (86.5) 0.14 195.5 (30.5) 0 129 (72.25) 0.02
0.4 4 93 (71.5) 0.12 143.5 (64.75) 0.01 136 (97.75) 0.08 187 (37) 0 133 (84.5) 0.10
0.8 4 18.5 (41.25) 0.63 73.5 (125.25) 0.28 72 (108.5) 0.29 183.5 (76) 0.03 61 (90.5) 0.39
400 0 4 71.5 (69.5) 0.44 110.5 (94) 0.27 99 (101.75) 0.36 199 (17) 0.02 119 (95) 0.22
0.4 4 60 (75.75) 0.56 136 (81.75) 0.14 135 (89.5) 0.17 194.5 (36.5) 0.01 126.5 (79) 0.14
0.8 4 6 (10) 1 60 (113.5) 0.52 26 (92.5) 0.67 184.5 (65.75) 0.07 35 (74.25) 0.63

II 200 0 3 4.5 (8) 0.95 15 (46.25) 0.70 101 (72.5) 0.07 53.5 (112.25) 0.45 26 (43.5) 0.67
0.4 3 3 (1) 1 14 (36.75) 0.69 76.5 (92.5) 0.26 189 (65.25) 0.09 28.5 (53) 0.59
0.8 3 3 (0) 1 12.5 (30.5) 0.76 13 (40.25) 0.72 200 (0) 0 4 (2) 0.99
400 0 3 3 (0) 1 3 (4) 0.97 108.5 (96) 0.30 20 (72.5) 0.68 10.5 (18.25) 0.92
0.4 3 3 (0) 1 4 (7) 0.97 41.5 (91.25) 0.61 199 (27.75) 0.10 14 (19) 0.91
0.8 3 3 (0) 1 5 (5.75) 0.98 5 (5) 0.96 200 (0) 0.01 3 (0.25) 1

III 200 0 4 53.5 (54.25) 0.33 96.5 (99.75) 0.20 93 (107.25) 0.21 183 (57.25) 0.02 108 (91.75) 0.14
0.4 4 42.5 (61.25) 0.45 82.5 (90.75) 0.21 109 (90.5) 0.18 170 (51.75) 0.01 86 (94.75) 0.18
0.8 4 4 (1) 0.99 6 (6.25) 0.94 7 (10.25) 0.88 188 (50) 0.01 13 (32.25) 0.75
400 0 4 48 (44.25) 0.67 86 (100.75) 0.40 113.5 (98) 0.28 174 (52) 0.03 102 (99) 0.31
0.4 4 14 (25.75) 0.91 48.5 (108.5) 0.55 75 (106.5) 0.47 179.5 (54.75) 0.08 68 (86) 0.49
0.8 4 4 (1) 1 6 (2) 0.99 5 (1) 1 197 (27.25) 0.02 7 (6.25) 0.98

IV 200 0 4 6.5 (9) 0.93 108 (86.75) 0.10 107 (103) 0.17 186.5 (58.25) 0.01 16 (28.25) 0.76
0.5 4 21 (43.5) 0.64 100 (82) 0.10 135 (75.75) 0.07 179.5 (36.5) 0.01 45.5 (84.5) 0.42
1 4 17 (37.25) 0.67 98 (89.5) 0.13 149 (72.75) 0.06 187 (29.25) 0 48 (68.5) 0.40
400 0 4 4 (0.25) 1 122 (116) 0.32 (101.5) (94.25) 0.31 189.5 (56.25) 0.08 4 (2) 0.99
0.5 4 7 (15.25) 0.95 86.5 (90.5) 0.35 144 (85.25) 0.16 182 (47.75) 0.01 18.5 (40.25) 0.83
1 4 6 (12.25) 0.95 93.5 (85.5) 0.34 154.5 (78) 0.12 186.5 (23.5) 0 41.5 (84.25) 0.63

V 200 0 4 4 (1) 0.98 125.5 (100.25) 0.10 104 (87.5) 0.11 190 (41) 0.01 49 (61.25) 0.37
0.5 4 5 (3) 0.96 136 (71.75) 0.05 183.5 (47.75) 0.01 183 (42.25) 0 24.5 (27.5) 0.72
1 4 11 (19.25) 0.79 172.5 (52.25) 0 197 (21.25) 0 168.5 (53.25) 0 42 (42.25) 0.43
400 0 4 4 (0) 1 96 (96.25) 0.31 105.5 (98.25) 0.34 192.5 (33) 0.01 17.5 (33) 0.83
0.5 4 4 (0) 1 144.5 (79.5) 0.17 190 (30.25) 0 176 (72.25) 0.05 10 (12.25) 0.99
1 4 5 (4) 0.98 178.5 (43.5) 0.01 199 (4.25) 0 164 (61.5) 0.05 30.5 (33) 0.87

VI 200 0 8 82 (82.5) 0.18 103 (85.75) 0.15 114 (96.25) 0.12 197 (14) 0 142.5 (70) 0
0.4 8 149 (71) 0.01 160 (57.75) 0.01 155 (93) 0.01 193 (20) 0 161 (52.75) 0
0.8 8 8 (2) 0.95 8 (4) 0.95 8.5 (2) 0.95 199 (5) 0 43.5 (67.25) 0.45
400 0 8 67.5 (71.25) 0.49 103 (94.25) 0.30 106.5 (108) 0.30 198.5 (9) 0 124.5 (62.5) 0.11
0.4 8 135 (59.25) 0.14 160 (59.75) 0.07 136.5 (88.75) 0.14 195.5 (19.25) 0 147 (65.25) 0.06
0.8 8 8 (0) 1 8 (0) 1 8 (0) 1 200 (2) 0 36 (45.75) 0.76

p*: number of truly important markers; ℛ: median of minimum model size that covers all important markers; IQR: inter-quartile range of minimum model size that covers all important markers; S: empirical probability that the set of top [n/log(n)] markers after screening includes all important markers.