Table 4.
Age-related gene expression changes in the left ventricle.
| Gene name | Gene symbol | Fold Regulation | p-value |
|---|---|---|---|
| FA METABOLISM | |||
| Acyl-CoA thioesterase 12 | Acot12 | 2.88 | 0.026 |
| Acyl-CoA thioesterase 7 | Acot7 | –1.86 | 0.017 |
| Acyl-CoA thioesterase 8 | Acot8 | –1.44 | 0.02 |
| Acyl-Coenzyme A oxidase 1, palmitoyl | Acox1 | –2.1 | 0.032 |
| Acyl-CoA synthetase bubblegum family member 1 | Acsbg1 | 2.09 | 0.034 |
| Acyl-CoA synthetase long-chain family member 6 | Acsl6 | –1.98 | 0.029 |
| 3-hydroxybutyrate dehydrogenase, type 1 | Bdh1 | –2.55 | 0.036 |
| Carnitine palmitoyltransferase 1c | Cpt1c | –1.49 | 0.027 |
| Carnitine palmitoyltransferase 2 | Cpt2 | –2.02 | 0.001 |
| Carnitine acetyltransferase | Crat | –2.69 | 0.011 |
| 2,4-dienoyl CoA reductase 1, mitochondrial | Decr1 | –2.05 | 0.03 |
| Enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | Echs1 | –2.39 | 0.004 |
| Enoyl-Coenzyme A delta isomerase 2 | Eci2 | –1.79 | 0.049 |
| Enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | Ehhadh | –3.29 | 0.034 |
| Fatty acid binding protein 3, muscle and heart | Fabp3 | –2.84 | 0.017 |
| Glutaryl-Coenzyme A dehydrogenase | Gcdh | –1.97 | 0.013 |
| Glycerol-3-phosphate dehydrogenase 2, mitochondrial | Gpd2 | –2.64 | 0.028 |
| Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit | Hadha | –2.23 | 0.035 |
| 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase | Hmgcl | –1.51 | 0.03 |
| Lipase, hormone sensitive | Lipe | –2.14 | 0.03 |
| Lipoprotein lipase | Lpl | –2.31 | 0.025 |
| Peroxisomal trans-2-enoyl-CoA reductase | Pecr | –1.67 | 0.013 |
| Pyrophosphatase (inorganic) 1 | Ppa1 | –1.78 | 0.03 |
| Protein kinase, AMP-activated, alpha 2 catalytic subunit | Prkaa2 | –2.09 | 0.034 |
| Protein kinase, AMP-activated, beta 1 non-catalytic subunit | Prkab1 | –3.96 | 0.041 |
| Protein kinase, AMP-activated, beta 2 non-catalytic subunit | Prkab2 | –1.7 | 0.041 |
| Protein kinase, cAMP-dependent, catalytic, alpha | Prkaca | –2.03 | 0.005 |
| Protein kinase, cAMP dependent, catalytic, beta | Prkacb | –1.65 | 0.031 |
| Protein kinase, AMP-activated, gamma 1 non-catalytic subunit | Prkag1 | –1.77 | 0.002 |
| Solute carrier family 27 (fatty acid transporter), member 1 | Slc27a1 | –2.02 | 0.03 |
| MITOCHONDRIAL FUNCTION | |||
| Peroxisome proliferator—activated receptor gamma, coactivator 1 alpha | Ppargc1 | –2.14 | 0.03 |
| NADH dehydrogenase (ubiquinone) Fe-S protein 7 | Ndufs7 | –2.24 | 0.015 |
| Ubiquinol - cytochrome c reductase, complex III subunit VII | Uqcrq | –1.48 | 0.05 |
| COX17 cytochrome c oxidase assembly homolog (S. cerevisiae) | Cox17 | –1.68 | 0.011 |
| Cytochrome c oxidase subunit IV isoform 1 | Cox4i1 | –1.72 | 0.02 |
| Cytochrome c oxidase subunit VIIa polypeptide 2 like | Cox7a2l | –1.35 | 0.049 |
| Mitofusin 1 | mfn1 | –2.41 | 0.01 |
| Mitofusin 2 | mfn2 | –3.21 | 0.028 |
| Clpb caseinolytic peptidase B homolog (E. coli) (i.e. HSP78) | clpb | –2.3 | 0.039 |
| Calcium/calmodulin-dependent protein kinase kinase 2, beta | Camkk2 | –1.77 | 0.017 |
| Serine/threonine kinase 11 (i.e. LKB1) | Stk11 | –1.86 | 0.029 |
| Peroxisome proliferator - activated receptor gamma, coactivator 1 beta | Ppargc1b | –2.69 | 0.012 |
| Tumor protein p53 | Tp53 | –2.19 | 0.025 |