Table 5.
Exercise-related changes in gene expression in Old FBN rats.
| Gene name | Gene symbol | Fold Regulation | p-value |
|---|---|---|---|
| GLUCOSE METABOLISM | |||
| Amylo-1,6-glucosidase, 4-alpha-glucanotransferase | Agl | –6.15 | 0.024 |
| Aldolase A, fructose-bisphosphate | Aldoa | –5.28 | 0.036 |
| Enolase 1, (alpha) | Eno1 | –4.1 | 0.042 |
| Enolase 2, gamma, neuronal | Eno2 | –3.27 | 0.019 |
| Glucose phosphate isomerase | Gpi | –5.59 | 0.005 |
| Glycogen synthase kinase 3 alpha | Gsk3a | –3.17 | 0.046 |
| Isocitrate dehydrogenase 3 (NAD+) beta | Idh3b | –7.7 | 0.04 |
| Isocitrate dehydrogenase 3 (NAD), gamma | Idh3g | –5.41 | 0.027 |
| Malate dehydrogenase 2, NAD (mitochondrial) | Mdh2 | –6.31 | 0.009 |
| Pyruvate dehydrogenase kinase, isozyme 1 | Pdk1 | –9.29 | 0.004 |
| Pyruvate dehydrogenase kinase, isozyme 2 | Pdk2 | –6.48 | 0.006 |
| Phosphoglucomutase 3 | Pgm3 | –1.7 | 0.037 |
| Phosphorylase kinase, gamma 1 | Phkg1 | –2.78 | 0.011 |
| Ribose 5-phosphate isomerase A | Rpia | –2.38 | 0.018 |
| Succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | Sdha | –3.93 | 0.038 |
| Succinate-CoA ligase, ADP-forming, beta subunit | Sucla2 | –5.64 | 0.021 |
| Solute carrier family 2 (facilitated glucose transporter), member 4 | Slc2a4 | –10.45 | 0.025 |
| FA METABOLISM | |||
| Acetyl-Coenzyme A acyltransferase 1A | Acaa1a | –9.79 | 0.001 |
| Acetyl-Coenzyme A acyltransferase 2 | Acaa2 | –11.7 | 0.029 |
| Acyl-Coenzyme A dehydrogenase family, member 10 | Acad10 | –7.02 | 0.002 |
| Acyl-Coenzyme A dehydrogenase family, member 11 | Acad11 | –14.38 | 0.002 |
| Acyl-Coenzyme A dehydrogenase family, member 9 | Acad9 | –8.81 | 0.008 |
| Acyl-Coenzyme A dehydrogenase, long-chain | Acadl | –21.18 | 0.002 |
| Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain | Acadm | –15.17 | 0.009 |
| Acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain | Acads | –17.09 | 0.001 |
| Acyl-Coenzyme A dehydrogenase, short/branched chain | Acadsb | –7.75 | 0.007 |
| Acyl-Coenzyme A dehydrogenase, very long chain | Acadvl | –9.49 | 0.002 |
| Acetyl-coenzyme A acetyltransferase 1 | Acat1 | –14.79 | 0.004 |
| Acetyl-Coenzyme A acetyltransferase 3 | Acat2 | –6.25 | 0.003 |
| Acyl-CoA thioesterase 2 | Acot2 | –18.92 | < 0.001 |
| Acyl-CoA thioesterase 3 | Acot3 | –3.52 | 0.024 |
| Acyl-CoA thioesterase 7 | Acot7 | –4.43 | 0.027 |
| Acyl-CoA thioesterase 8 | Acot8 | –2.68 | 0.002 |
| Acyl-CoA thioesterase 9 | Acot9 | –5.41 | 0.001 |
| Acyl-Coenzyme A oxidase 1, palmitoyl | Acox1 | –5.16 | 0.007 |
| Acyl-Coenzyme A oxidase 3, pristanoyl | Acox3 | –4.47 | 0.015 |
| Acyl-CoA synthetase long-chain family member 1 | Acsl1 | –18.06 | < 0.001 |
| Acyl-CoA synthetase long-chain family member 3 | Acsl3 | –3.6 | 0.008 |
| Acyl-CoA synthetase long-chain family member 4 | Acsl4 | –2.46 | 0.011 |
| Acyl-CoA synthetase long-chain family member 5 | Acsl5 | –2.23 | 0.001 |
| Acyl-CoA synthetase long-chain family member 6 | Acsl6 | –5.54 | 0.01 |
| 3-hydroxybutyrate dehydrogenase, type 1 | Bdh1 | –10.48 | 0.04 |
| 3-hydroxybutyrate dehydrogenase, type 2 | Bdh2 | –5.03 | 0.008 |
| Carnitine palmitoyltransferase 1a, liver | Cpt1a | –3.04 | 0.033 |
| Carnitine palmitoyltransferase 1b, muscle | Cpt1b | –7.93 | 0.003 |
| Carnitine palmitoyltransferase 2 | Cpt2 | –7.02 | 0.004 |
| Carnitine acetyltransferase | Crat | –4.27 | 0.018 |
| Fatty acid binding protein 3, muscle and heart | Fabp3 | –7.31 | 0.034 |
| Protein kinase, AMP-activated, alpha 1 catalytic subunit | Prkaa1 | 1.83 | 0.042 |
| Protein kinase, cAMP-dependent, catalytic, alpha | Prkaca | –2.89 | 0.041 |
| Protein kinase, cAMP dependent, catalytic, beta | Prkacb | –1.43 | 0.047 |
| Solute carrier family 27 (fatty acid transporter), member 1 | Slc27a1 | 1.73 | 0.033 |
| Solute carrier family 27 (fatty acid transporter), member 4 | Slc27a4 | 3.15 | 0.002 |
| CD36 molecule (thrombospondin receptor) | CD36 | –2.97 | 0.001 |
| Peroxisome proliferator activated receptor alpha | Ppara | –9.28 | 0.029 |
| MITOCHONDRIAL FUNCTION | |||
| Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) | Sirt1 | –3.27 | 0.036 |
| NADH dehyrogenase (ubiquinone) 1 alpha subcomplex, 1 | Ndufa1 | –2.24 | 0.04 |
| NADH dehyrogenase (ubiquinone) 1 alpha subcomplex, 6 (B14) | Ndufa6 | –4.7 | 0.041 |
| NADH dehyrogenase (ubiquinone) 1 alpha subcomplex, 7 | Ndufa7 | –5.67 | 0.033 |
| NADH dehyrogenase (ubiquinone) 1 alpha subcomplex, 8 | Ndufa8 | –10.41 | 0.005 |
| NADH dehyrogenase (ubiquinone) 1 alpha subcomplex, 9 | Ndufa9 | –5.71 | 0.018 |
| NADH dehyrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 | Ndufab1 | –5.67 | 0.001 |
| NADH dehyrogenase (ubiquinone) 1 beta subcomplex, 2 | Ndufb2 | –4.49 | 0.006 |
| NADH dehyrogenase (ubiquinone) 1 beta subcomplex, 5 | Ndufb5 | –4.72 | 0.032 |
| NADH dehyrogenase (ubiquinone) 1 beta subcomplex, 8 | Ndufb8 | –4.92 | 0.01 |
| NADH dehyrogenase (ubiquinone) Fe-S protein 6 | Ndufs6 | –2.94 | 0.047 |
| Cytochrome c-1 | Cyc1 | –5.47 | 0.033 |
| Ubiquinol-cytochrome c reductase core protein 2 | Uqcrc2 | –5.38 | 0.016 |
| Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 | Uqcrfs1 | –5.11 | 0.045 |