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Distinct genetic alterations in type I and type II endometrial cancer (percentage is based on several publications, showing only a general tendency) [24–26]
| Mutation | Type I | Type II |
|---|---|---|
| PTEN | 50-80% | 1-10% |
| KRAS | 20-40% | 4-8% |
| CTNNB1 | 25% | uncommon |
| PIK3CA | 40-50% | 20-40% |
| PIK3R1 | 20-40% | < 10% |
| ARID1A | 25-50% | 5-10% |
| TP53 | 10% | 80-90% |
| HER2 | very uncommon | 30-40% |
| MSI | 30-40% | uncommon |
| PPP2R1A | < 10% | 10-40% |
