Tab. III.

Overview of the TGCA subgroups [26–29]

Parameter	POLE ultramutated	MSI+/hypermutated	Copy number low/MSS	Copy number high/serous-like
Mutation rate	232 × 10-6/Mb	18 × 10-6/Mb	2.9 × 10-6/Mb	2.3 × 10-6/Mb
Histological type	endometrioid	endometrioid	mainly endometrioid	endometrioid, serous and mixed
Grade	G1-G3	G1-G3	predominance of G1-G2	G3
Survival	favourable	intermediate	intermediate	poor
Mutated genes – most important examples (%)	POLE (100%) PTEN (94.1%) MUC16 (94.1%) RGDP13 (94.1%) PIK3CA (71%) PIK3RI (65%) KRAS (53%) ARID1A (76%) GPR112 (94.1%) CCNB3 (94.1%) SLITRK3 (94.1%) DNAH5 (94.1%) APOB (94.1%) LAMA2 (94.1%) NBEA (94.1%)	PTEN (87.7%) PIK3CA (53.8%) PIK3R1 (41.5%) ARID1A (36.9%) RPL22 (36.9%) KRAS (35.4%) ZFHX3 (30.8%) ARID5B (23.1%) CTNNB1 (20%) FGFR2 (13.8%)	PTEN (76.7%) PIK3CA (53.3%) CTNNB1 (52.2%) ARID1A (42.2%) PIK3R1 (33.3%) CTFC (21.1%) KRAS (15.6%) FGFR2 (13.3%)	TP53 (91.7%) PIK3CA (46.7%) FBXW7 (21.7%) PPP2R1A (21.7%) PIK3R1 (13.3%) CHD4 (13.3%) PTEN (10.0%)