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. 2016 Aug 23;6:31506. doi: 10.1038/srep31506

Figure 4. Treatment with miR-214 inhibitor ameliorated the glomerular mesangial expansion in db/db mice.

Figure 4

(A) UAE in db/db mice. (B) mRNA expresion of miR-214 in glomeruli. (C) Representative images of PAS staining for glomerular mesangial expansion in mice (original magnification ×400). Scale bars: 20 μm. (D) Quantitative analysis of mesangial score in mice. (E) Representative electron micrographs in mice (original magnification ×10000). Scale bars: 2 μm. The arrows marked some mesangial areas. db/m, db/m control mice; db/db, diabetic db/db mice; ScRNA, db/db mice treated with miR-214 scramble; anti-miR-214, db/db mice treated with miR-214 inhibitor. All data were expressed as means ± SD, ▲p < 0.05 vs. db/db group, ★p < 0.05 vs. ScRNA group.