| Cluster 1—Immune-evasion subtype |
| EGFR_UP.V1_UP |
<0.001 |
<0.001 |
Genes upregulated in MCF-7 cells (breast cancer) positive for ESR1 and engineered to express ligand-activatable EGFR |
| RAF_UP.V1_UP |
<0.001 |
<0.001 |
Genes upregulated in MCF-7 cells (breast cancer) positive for ESR1 MCF-7 cells (breast cancer) stably over-expressing constitutively active RAF1 |
| HINATA_NFKB_IMMU_INF |
<0.001 |
0.004 |
Immune or inflammatory genes induced by NF-kappaB in primary keratinocytes and fibroblasts |
| |
|
|
|
| Cluster 2—Replication-stress associated subtype |
| REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS |
<0.001 |
0.005 |
Genes involved in activation of ATR in response to replication stress |
| NFE2L2.V2 |
0.093 |
<0.001 |
Genes upregulated in MEF cells (embryonic fibroblasts) with knockout of NFE2L2 |
| SIRNA_EIF4GI_UP |
0.432 |
<0.001 |
Genes upregulated in MCF10A cells vs knockdown of EIF4G1 gene by RNAi |
| |
|
|
|
| Cluster 3—Neuroendocrine subtype |
| CAHOY_NEURONAL |
<0.001 |
0.036 |
Genes upregulated in neurons |
| BCAT_GDS748_DN |
0.137 |
— |
Genes regulated in HEK293 cells (kidney fibroblasts) expressing constitutively active form of CTNNB1 gene |
| BCAT_GDS748_UP |
— |
0.003 |
|
| ESC_V6.5_UP_EARLY.V1_UP |
0.033 |
<0.001 |
Genes upregulated during early stages of differentiation of embryoid bodies from V6.5 embryonic stem cells |
