Table 1. LOD-score, position and interactions of QTLs in the three respective models.
| Phenotype | QTL | LOD score | Chr | Bayesian credible interval (cM) | Nearest marker | Interactions | Full model statistics | Variance explained |
|---|---|---|---|---|---|---|---|---|
| Number of DNs in SNpc | En1a | 13.1 | 16 | 28.9–30.4 | rs4180773 | En1c | p = 2.4E-09 LOD = 28.3 (12.2) | 74% |
| En1b | 11.3 | 14 | 27.2–34.9 | rs3695574 | En1d | |||
| En1c | 10.5 | 14 | 14.3–22.4 | rs3695383 | En1a. En1g | |||
| En1d | 10.0 | 2 | 28.2–29.0 | rs13476490 | En1b | |||
| En1e | 8.8 | 2 | 36.0–67.8 | rs3658729 | En1f | |||
| En1f | 7.7 | 11 | 69.5–72.9 | rs13481230 | En1e | |||
| En1g* | 5.8 | 9 | 5.9–12.0 | rs13480107 | En1c | |||
| En1h* | 3.0 | 18 | 31.7–46.5 | rs6320743 | ||||
| Number of axonal swellings per DN | En1i | 25.2 | 15 | 19.9–22.3 | rs3674266 | En1k, En1j, En1l | p = 1.7E-12 LOD = 32. (10.1) 4 | 80% |
| En1j | 20.7 | 4 | 10.8–16.2 | rs3653593 | En1i, En1m | |||
| En1k | 15.1 | 6 | 58.1–68.4 | rs3152403 | En1i | |||
| En1l | 13.2 | 9 | 61.2–63.4 | rs3694903 | En1i | |||
| En1m | 12.7 | 3 | 76.8–83.1 | rs3724562 | En1j | |||
| En1n* | 4.3 | 18 | 20.1–36.0 | rs3669543 | ||||
| En1o* | 4.1 | 2 | 68.3–83.8 | rs6376291 | ||||
| Average size of axonal swellings | En1p | 21.0 | 6 | 72.1–77.6 | rs6387265 | En1q, En1r, En1s | p = 7.0E-11 LOD = 30.2 (14.1) | 74% |
| En1q | 12.1 | 15 | 23.9–30.9 | rs3699312 | En1p | |||
| En1r | 10.8 | 14 | 69.2–78.4 | rs3698545 | En1p | |||
| En1s | 10.3 | 2 | 34.7–42.7 | rs13476507 | En1p | |||
| En1t* | 8.1 | 13 | 61.2–69.7 | rs6316705 | En1u | |||
| En1u* | 7.8 | 7 | 15.7–36.2 | rs3696018 | En1t | |||
| En1v* | 3.8 | 4 | 9.8–22.8 | rs3653593 | ||||
| En1x* | 3.7 | 14 | 14.2–29.2 | rs3695383 |
Full model statistics include p-value and LOD scores for the full QTL model with significance LOD threshold in parentheses.
*Individual QTL below the respective genome-wide significance LOD threshold (Number of DNs in SNpc = 7.1, Number of axonal swellings per DN = 4.8, Average size of axonal swellings = 8.7). LOD: Logarithm of odds, QTL: quantitative trait locus, DN: Dopaminergic neuron, SNpc: Substantia nigra pars compacta.