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. 2016 Aug 23;6:31916. doi: 10.1038/srep31916

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Copyright © 2016, The Author(s)

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(a) The system enabled a circular flow of the culture medium for continuous heating, oxygenation and tissue perfusion. Simultaneous sample taking before and after the liver passage allowed for surveillance of oxygen consumption. By pH measurement and inflow of sodium bicarbonate pH was maintained in a physiological range. (b) Schedule of the perfusion runs with time points of liver function tests, start of extra-circular addition of fresh medium and application of APAP for toxicity experiments.