Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Aug 23;6:31931. doi: 10.1038/srep31931

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

YAP1/TAZ activation in Sav1-depleted cells induces TGF-β and TβRII mRNA expression, thereby synergistically enhancing responsiveness to TGF-β. This mechanism promotes TGF-β-induced EMT-like phenotypic changes and contributes to progressive renal TIF. Sav1 depletion also enhances Wnt/β-catenin activation, which exacerbates TIF.