Table 2. Diagnostic models used for variance component linkage analyses of the original and extended family.
| Model | Diagnoses | N |
LOD | ||
|---|---|---|---|---|---|
| t(1;11) carriers | t(1;11) non-carriers | ALL | |||
|
Original family | |||||
| Model 1 | SCZ, SCZAFF | 7 | 0 | 7 | 1.7 |
| Model 2 | BP1, rMDD | 12 | 0 | 12 | 2.2 |
| Model 3 | SCZ, SCZAFF, BP1, rMDD | 19 | 0 | 19 | 3.8 |
| Unaffected | 7 | 21 | 28 | ||
| Unknown | 2 | 1 | 3 | ||
| Total | 30 | 28 | 58 | ||
|
Extended family | |||||
| Model 1 | SCZ, SCZAFF | 6 | 0 | 6 | 3.3 |
| Model 2 | BP1, rMDD | 10 | 3 | 13 | 3.5 |
| Model 3 | SCZ, SCZAFF, BP1, rMDD | 16 | 3 | 19 | 6.1 |
| Model 3+cyclothymia | SCZ, SCZAFF, BP1, rMDD, cyclothymia | 19 | 3 | 22 | 7.9 |
| Unaffected | 2 | 53 | 55 | ||
| Unknown | 8 | 8 | 16 | ||
| Total | 37 | 70 | 107 | ||
Abbreviations: BP1, bipolar 1; MDD, single episode depression; rMDD, recurrent major depressive disorder; SCZ, schizophrenia; SCZAFF, schizoaffective disorder.
For comparison, the original family (Blackwood et al.2) and the extended family two-point LOD scores are shown. Bold=LOD scores>3.