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. Author manuscript; available in PMC: 2016 Aug 23.
Published in final edited form as: Eur J Med Chem. 2013 Oct 9;70:273–279. doi: 10.1016/j.ejmech.2013.10.003

Scheme 1.

Scheme 1

Preparation of compounds 3a and 3b. Reagents and conditions: a: potassium carbonate/absolute ethanol, reflux, 12 h; b: methyl iodide, potassium carbonate, dry DMF, RT, 3 h; c: hydrazine hydrate/absolute ethanol, reflux, 12 h.