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. 2016 Aug 22;13(1):28. doi: 10.1186/s12950-016-0136-1

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — MCP-1 is not required for hepatocyte proliferation after PH. a Liver-body weight ratios (mean +/− SEM) of wild type and MCP-1 knockout mice at the indicated times after PH. Sample size varied due to the limited availability of MCP-1 knockout mice. The numbers above the data bars indicate how many MCP-1 knockout mice were used at each time point; an identical number of wild-type mice were used at that same time point. b Percentage (mean +/− SEM) of BrdU⁺ hepatocyte nuclei from wild type or MCP-1 knockout mice at the indicated times after PH. Mice were pulsed with BrdU 2 h prior to euthanasia at the indicated time points (n = 6 at 0 and 24 h; n = 10 at 36 and 48 h). c Representative BrdU incorporation in regenerating liver tissue from wild type and MCP-1 knockout mice 6 days after PH; BrdU was added to the drinking water continuously for 6 days. d Cumulative BrdU incorporation in the regenerating liver of wild type and MCP-1 knockout mice administered BrdU in their drinking water for 6 days post-PH. Data represent the percentage (mean +/− SEM) of BrdU⁺ hepatocyte nuclei from 4 wild-type mice and 4 MCP-1 knockout mice. Means at each time point were not statistically significant from each other based on two-way ANOVA (Fig. 4 a, b) or Student’s t-test (Fig. 4 d)