Table 3.
The effects of high calorie diet (± metformin) on gene expression in maternal and fetal livers
| Maternal livers | Fetal Livers | |||||
|---|---|---|---|---|---|---|
| Gene | NORM mean (±SD) | HCAL mean (±SD) | HCAL + MET mean (±SD) | NORM mean (±SD) | HCAL mean (±SD) | HCAL + MET mean (±SD) |
| Chrebp | 1.0 (±0.33) | 0.9 (±0.19) | 1.1 (±0.41) | 1.0 (±0.25) | 1.1 (±0.34) | 0.9 (±0.46) |
| D5d | 1.0 (±0.36) | 1.2 (±0.23) | 1.4 (±0.27) | 1.0 (±0.34) | 1.5 (±0.44)a* | 1.4 (±0.34) |
| D6d | 1.0 (±0.49) | 1.1 (±0.33) | 1.5 (±0.26) | 1.0 (±0.31) | 1.5 (±0.23)a*** | 1.6 (±0.26) |
| D9d (Scd1) | 1.0 (±0.68) | 1.2 (±0.35) | 1.3 (±0.33) | 1.0 (±0.33) | 1.4 (±0.37)a* | 1.2 (±0.28) |
| Elovl2 | 1.0 (±0.39) | 0.9 (±0.24) | 0.8 (±0.13) | 1.0 (±0.23) | 1.1 (±0.30) | 1.0 (±0.32) |
| Elovl5 | 1.0 (±0.14) | 1.0 (±0.24) | 1.1 (±0.06) | 1.0 (±0.12) | 1.5 (±0.86) | 1.1 (±0.18) |
| Elovl6 | 1.0 (±0.37) | 0.8 (±0.26) | 1.0 (±0.43) | 1.0 (±0.15) | 1.1 (±0.16) | 1.3 (±0.25) |
| Fasn | 1.0 (±0.46) | 1.0 (±0.47) | 1.1 (±0.39) | 1.0 (±0.18) | 1.5 (±0.28)a*** | 1.6 (±0.37) |
| Lxrα | 1.0 (±0.13) | 1.0 (±0.09) | 1.1 (±0.14) | 1.0 (±0.13) | 1.2 (±0.30)a** | 1.3 (±0.30) |
| Lxrβ | 1.0 (±0.42) | 1.0 (±0.11) | 1.0 (±0.13) | 1.0 (±0.13) | 1.0 (±0.14) | 1.0 (±0.13) |
| Srebf1 | 1.0 (±0.29) | 1.8 (±0.36)a*** | 1.7 (±0.38) | 1.0 (±0.23) | 1.3 (±0.40) | 1.2 (±0.19) |
NORM normal diet, HCAL high calorie diet, MET metformin, SD standard deviation
aNORM vs. HCAL; *p = <0.05; **p < 0.01, ***p < 0.001
Data are presented as relative mRNA expression (mean ± SD), with the normal-fed group set to 1.0