Table 5.
Effects of maternal HCAL diet (±metformin) on fetal brain FA profiles
| Fatty acid | NORM mean (±SD) | HCAL mean (±SD) | HCAL + MET mean (±SD) | |
|---|---|---|---|---|
| SFA | 14.0 | 1.9 (±0.08) | 2.0 (±0.05) | 2.0 (±0.23) |
| 16.0 | 33.4 (±0.89) | 33.6 (±0.93) | 32.8 (±0.27) | |
| 18.0 | 17.8 (±0.81) | 17.5 (±0.52) | 16.9 (±0.30) | |
| MUFA | 16.1n7 | 2.2 (±0.21) | 2.2 (±0.10) | 2.3 (±0.12) |
| 18.1n9 | 13.6 (±0.56) | 13.9 (±0.30) | 14.3 (±0.39) | |
| 18.1n7 | 3.9 (±0.19) | 3.9 (±0.26) | 4.0 (±0.21) | |
| PUFA | 20.4n6 | 13.2 (±0.42) | 12.5 (±0.35)a* | 13.0 (±0.41) |
| 22.4n6 | 3.2 (±0.12) | 2.9 (±0.03)a** | 3.0 (±0.17) | |
| 22.5n6 | 2.9 (±0.24) | 2.3 (±0.22)a** | 2.7 (±0.22)b* | |
| 22.6n3 | 7.0 (±0.75) | 8.6 (±1.53)a* | 8.0 (±0.35) | |
NORM normal diet, HCAL high calorie diet, MET metformin, SD standard deviation, SFA saturated fatty acids, MUFA monounsaturated fatty acids, PUFA polyunsaturated fatty acids
aNORM vs. HCAL,b HCAL vs. HCAL + MET; *p < 0.05, **p < 0.01
Data are expressed as mean ± SD (mg/100 mg)