Table 6.
The effects of HCAL diet (± metformin) on gene expression in fetal brains
| Gene | NORM mean (±SD) | HCAL mean (±SD) | HCAL + MET mean (±SD) |
|---|---|---|---|
| Chrebp | ND | ND | ND |
| D5d | 1.0 (±0.14) | 0.9 (±0.13) | 1.0 (±0.19) |
| D6d | 1.0 (±0.06) | 0.9 (±0.12) | 1.1 (±0.09) |
| D9d (Scd1) | 1.0 (±0.06) | 0.9 (±0.11)a*** | 0.8 (±0.05) |
| Elovl2 | 1.0 (±0.10) | 1.4 (±0.42) | 1.5 (±0.08) |
| Elovl5 | 1.0 (±0.20) | 1.0 (±0.14) | 1.0 (±0.10) |
| Elovl6 | 1.0 (±0.15) | 0.9 (±0.17) | 1.1 (±0.16) |
| Fasn | 1.0 (±0.13) | 1.0 (±0.07) | 1.0 (±0.10) |
| Lxrα | 1.0 (±0.01) | 1.2 (±0.07) | 1.4 (±0.29) |
| Lxrβ | 1.0 (±0.19) | 0.9 (±0.09) | 0.8 (±0.22) |
| Srebf1 | 1.0 (±0.14) | 1.1 (±0.23) | 1.0 (±0.27) |
NORM normal diet, HCAL high calorie diet, MET metformin, SD standard deviation
aNORM vs. HCAL; ***p < 0.001
Data are presented as relative mRNA expression (mean ± SD), with the normal-fed group set to 1.0