Fig. 9.

Signaling consequences of dimerization and oligomerization by the tandem SAM domains of CASKIN2. In its oligomeric form, CASKIN2 would provide a vast array of interaction sites with enhanced avidity for many proteins through its available intrinsically unstructured regions and ankyrin repeats. In its dimeric form, CASKIN2 could fulfill a classic adaptor role bringing together protein partners that potentially depend on dimerization themselves for coupling and activation