Table 2.
Muscle structure in both diaphragm and gastrocnemius muscles of mice of the 20-week cohort
| Controls | U | E–U | |
|---|---|---|---|
| Diaphragms | |||
| Fiber type proportions | |||
| Type I fibers (%) | 8.9 (1.66) | 9.5 (1.70) | 8.3 (1.05) |
| Type II fibers (%) | 91.1 (1.66) | 90.5 (1.70) | 91.7 (1.05) |
| Cross-sectional area | |||
| Type I fibers (μm2) | 342.7 (61.9) | 235.7 (32.5)*** | 155.3 (41.5)***, § |
| Type II fibers (μm2) | 473.2 (43.0) | 328.2 (30.4)*** | 230.6 (50.5)***, §§§ |
| Gastrocnemius | |||
| Fiber type proportions | |||
| Type I fibers (%) | 25.1 (7.28) | 20.6 (4.82) | 20.7 (6.74) |
| Type II fibers (%) | 74.9 (7.28) | 79.4 (4.82) | 79.3 (6.74) |
| Cross-sectional area | |||
| Type I fibers, (μm2) | 746.6 (69.6) | 504.5 (123.5)*** | 491.4 (47.3)*** |
| Type II fibers, (μm2) | 691.4 (65.7) | 622.4 (61.8)* | 568.5 (31.3)*** |
Variables are presented as mean (standard deviation)
U urethane, E–U elastase–urethane
Statistical significance: * p ≤ 0.05 and *** p ≤ 0.001 between any of the experimental groups and the control mice
§p ≤ 0.05 and §§§p ≤ 0.001 between urethane and elastase–urethane groups of mice