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. 2016 Aug 22;4(1):87. doi: 10.1186/s40478-016-0364-x

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — RNA sequencing analysis of microglia. a Multidimensional scaling plot of microglia RNAseq data from different mice. αSYN^tg/tg microglia from mice with a phenotype cluster separately from all other microglia samples and are most similar to αSYN^tg/tg G3Terc^-/- microglia. Gene expression in control and αSYN^tg/tg microglia without a phenotype are very similar and form a separate, mixed cluster. b Volcano plots showing the significantly differentially expressed genes between pairs of conditions. Dark red dots: FDR <0.05 and logFC >1 and bright red dots: FDR <0.0001 and logFC >3. c The number of differentially expressed genes (up, down and total) between the compared groups. d Heatmap visualization of genes differentially expressed between αSYN^tg/tg and αSYN^tg/tg G3Terc samples (FDR <0.001, logFC >3)