Additional file 2.
The cancer cell population regains cytotoxic-drug sensitivity when drug delivery is discontinued. This movie shows the evolution of an initial population which is mainly composed of highly proliferative cells (i.e., cells in the phenotypic state x=0) exposed to periodic phases of high-dose delivery (drug dose corresponding to the LC90) separated by drug-free periods. The values of the model parameters are as in Table 1. The red and blue lines highlight the highly proliferative state x=0 and the highly drug-resistant state x=1. In agreement with the experimental results presented in [62], these results clearly show that administering the cytotoxic drug in an alternate fashion leads to the emergence of cycling subpopulations of drug-resistant and drug-sensitive cells. (MOV 415 kb)