Table. Characteristics of 3 extremely preterm infants with Bifidobacterium longum subspecies infantis bacteremia, 2015*.
| Characteristic | Patient 1 | Patient 2 | Patient 3 |
|---|---|---|---|
| NICU | A | B | A |
| Sex | M | M | F |
| Date of onset | Apr | Jul | Sep |
| Gestational age, wk | 24 | 23 | 24 |
| Birth weight, g | 730 | 500 | 697 |
| Mode of delivery | Vaginal | Vaginal | Caesarean section |
| Apgar score at 1, 5, and 10 min after birth | 4, 5, 5 | Unknown, 0, 4 | 2, 2, 3 |
| Reason for prematurity | Preterm rupture of membranes, maternal infection | Sudden preterm rupture of membranes, delivery not attended by healthcare personnel | Placental abruption |
| Age at onset of sepsis, d | 8 | 12 | 46 |
| Maximum CRP level, mg/L, <48 h of symptom onset | 147 | 25 | 242 |
| Age at discharge, wk | 40 | 41 | 43 |
| Weight at discharge, kg | 3.3 | 3.4 | 3.3 |
| Bacterial culture medium and conditions | BacT/ALERT,† aerobic, 36°C | BACTEC Plus,† aerobic, 35°C | BacT/ALERT,† aerobic, 36°C |
| Bacterial growth in blood culture, d | 2 | 3 | 2 |
*Patients were given ½ to 1 capsule/day of oral probiotics (Infloran; Laboratorio Farmacéutico Specialità Igienico Terapeutiche, Mede, Italy) that contained 109 Lactobacillus acidophilus (ATCC 4356) and 109 B. longum subspecies infantis (ATCC 15697). MICs (mg/L) for antimicrobial drugs tested were 0.016 for meropenem, 0.032 for ampicillin, 0.064 for penicillin, 0.064 for piperacillin/tazobactam, 0.250 for cefotaxime, 0.250 for clindamycin, 0.250 for vancomycin, and 4.000 for ciprofloxacin. All bacterial strains were inherently resistant to aminoglycosides. ATCC, American Type Culture Collection (Manassas, VA, USA); CRP, C-reactive protein; NICU, neonatal intensive care unit. †bioMérieux (Marcy l’Étoile, France).