Table 4. Predictors of unfavorable outcome among patients initiating treatment for extensively drug-resistant tuberculosis, KwaZulu-Natal and Eastern Cape Provinces, South Africa, 2006–20010*.
| Predictor | Unadjusted analysis |
Multivariate analysis |
|||
|---|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | ||
| HIV positive | 1.37 (1.09–1.72) | 0.005 | 1.35 (1.06–1.72) | 0.02 | |
| Previous MDR TB treatment | 0.96 (0.76–1.23) | 0.76 | 1.04 (0.77–1.42) | 0.78 | |
| Smear positive | 1.34 (1.07–1.68) | 0.01 | 1.25 (0.97–1.62) | 0.09 | |
| Age | 0.99 (0.98–1.00) | 0.25 | 0.100 (0.100–1.01) | 0.69 | |
| Weight <50 kg | 1.66 (1.33–2.08) | <0.0001 | 1.56 (1.23–1.98) | 0.0003 | |
| KwaZulu Province | 1.00 (0.78–1.28) | 0.99 | 0.92 (0.67–1.26) | 0.60 | |
| Male sex | 0.92 (0.74–1.14) | 0.43 | 0.99 *0.77–1.27) | 0.94 | |
| Cavitary disease by chest radiograph | 0.99 (0.78–1.26) | 0.94 | 0.99 (0.76–1.30) | 0.96 | |
*p values in bold are statistically significant. HR, hazard ratio; MDR TB, multidrug-resistant tuberculosis.