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. 2016 Aug 22;16(1):667. doi: 10.1186/s12885-016-2693-3

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Western Blot analysis of E-cadherin and N-cadherin in HT-144 and A375 melanoma cell lines treated with HDACi during 24 h. Figure shows images from a representative experiment. Both E- and N-cadherin upregulation was observed in the two cell lines, specially with butyrate and valproic acid. Vimentin expression was induced by the four inhibitors in A375 cells but only butyrate had a significant effect on HT-144 cell line. Tubulin was used as a loading control to normalize protein content. Abbreviations: But, butyrate; TSA, Trichostatin A; VPA, valproic acid; Vor, vorinostat.