Table 2.
Overall positivity, sensitivity for CIN3+ and CIN2+, specificity for < CIN2 and agreement for different tests and transport media.
| Overall positivity (%) | Sensitivity |
Specificity | ||
|---|---|---|---|---|
| CIN3+ (N = 96)c | CIN2+ (N = 176)c | <CIN2 (N = 454)c | ||
| HC2 (N = 344) | ||||
| PreservCyt | 289 (84) | 0.98 | 0.97 | 0.21 |
| SurePath | 269 (78) | 0.98 | 0.96 | 0.28 |
| Agreement (%) | 89.5 | 95.6 | 94.5 | 87.7 |
| Discordanta | 28 vs 8 | 1 vs 1 | 3 vs 2 | 25 vs 6 |
| P-valueb | 0.001 | 1 | 1 | 0.001 |
| RealTime (N = 630) | ||||
| PreservCyt | 476 (76) | 0.99 | 0.95 | 0.32 |
| SurePath | 447 (71) | 0.97 | 0.91 | 0.37 |
| Agreement (%) | 93.8 | 95.8 | 94.3 | 93.6 |
| Discordanta | 34 vs 5 | 3 vs 1 | 8 vs 2 | 26 vs 3 |
| P-valueb | 2.4 × 10−6 | 0.62 | 0.11 | 1.5 × 10−5 |
| Onclarity (N = 630) | ||||
| PreservCyt | 486 (77) | 1.00 | 0.97 | 0.31 |
| SurePath | 494 (78) | 1.00 | 0.97 | 0.29 |
| Agreement (%) | 97.1 | 100 | 100 | 96 |
| Discordanta | 5 vs 13 | 0 vs 0 | 0 vs 0 | 5 vs 13 |
| P-valueb | 0.10 | 1 | 1 | 0.10 |
| PapType (N = 585) | ||||
| PreservCyt | 465 (79) | 0.96 | 0.93 | 0.26 |
| SurePath | 469 (80) | 0.96 | 0.94 | 0.25 |
| Agreement (%) | 93.5 | 93.4 | 95.8 | 92.6 |
| Discordanta | 17 vs 21 | 3 vs 3 | 3 vs 4 | 14 vs 17 |
| P-valueb | 0.63 | 1 | 1 | 0.72 |
| Aptima (N = 613) | ||||
| PreservCyt | 476 (78) | 100 | 0.98 | 0.30 |
| SurePath | 446 (73) | 0.99 | 0.93 | 0.35 |
| Agreement (%) | 90.2 | 100 | 95.4 | 88.1 |
| Discordanta | 45 vs 15 | 0 vs 0 | 8 vs 0 | 37 vs 15 |
| P-valueb | 1.3 × 10−4 | 1 | 0.01 | 0.003 |
| OncoHealth (N = 630) | ||||
| PreservCyt | 356 (57) | 0.58 | 0.60 | 0.45 |
| SurePath | 301 (48) | 0.55 | 0.52 | 0.54 |
| Agreement (%) | 55.4 | 46.9 | 49.4 | 57.7 |
| Discordanta | 168 vs 113 | 27 vs 24 | 51 vs 38 | 117 vs 75 |
| P-valueb | 0.001 | 0.78 | 0.203 | 0.003 |
a
PreservCyt+/SurePath- vs SurePath+/PreservCyt-.
b
McNemar’s test.
c
Number refers to the whole population of N = 630. See Fig. 1 for reduced numbers for HC2, PapType and Aptima.