Figure 6.

Quantitative real-time polymerase chain reaction analysis of MMP-related genes in the sciatic nerve at 0, 1, 4, 7, and 14 days following injury.

The relative expression of each mRNA was calculated using comparative Ct with GAPDH as the reference gene. *P < 0.05, **P < 0.01, ***P < 0.0001, vs. control group (uninjured rats). Data are summarized from 3–4 paired experiments and values are shown as the mean ± SEM (one-way analysis of variance and the least significant difference test). GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; MMP: matrix metalloproteinase; ADAM: a disintegrin and metalloproteinase with thrombospondin motifs; TIMP: tissue inhibitors of metalloproteinase.