Table 1. Toxicity Management.

Toxicity	Grade	Action
Cytokine Release Syndrome	3	Withhold infusion until resolved, then restart at 9 mcg/d*
	4	Permanently discontinue
Neurologic Toxicity	Seizure	If more than one seizure occurs, permanently discontinue blinatumomab
	Grade 3	Withhold the infusion until resolved to ≤ Grade 1 for at least 3 days, then restart at 9 mcg/d*. If the toxicity does not recur after 7 days, escalate to 28 mcg/d*. If the toxicity recurs or if it takes more than 7 days to resolve, permanently discontinue blinatumomab.
	Grade 4	Permanently discontinue
Other Clinically Relevant Adverse Reactions	Grade 3	Withhold the infusion until resolved to ≤ Grade 1 for at least 3 days, then restart at 9 mcg/d*. If the toxicity does not recur after 7 days, escalate to 28 mcg/d*. If the toxicity takes more than 14 days to resolve, permanently discontinue.
	Grade 4	Consider permanent discontinuation.

^*Dexamethasone 20 mg should be administered 1 hour prior to the reinitation of infusion (If blinatumomab was held for more than 4 hours) and prior to dose increases.