Table 2.

Factors related to efficacy of second-course ophthalmic artery chemosurgery

VARIABLE	COMPARISON		p-value
		n	PFS	OS
Vitreous seeds	Presence vs. absence of vitreous seeds	29	0.35	0.03
Prior treatment status	Prior treated vs naïve	29	0.40	0.86
Latency of relapse	Interval btwn initial OAC end & relapse <4.4mos vs >=4.4mos	29	0.22	0.34
Age at initial OAC	Age <1yr or <= 1 yr during initial OAC	29	0.45	0.15
No. of initial infusions	<3 infusions vs >= 3 infusions during initial OAC	29	0.56	0.23
Addition of new drug	Absence vs addition of new drug during 2nd course	29	0.93	0.23
No. of 2nd infusions	1 vs >1 infusion during 2nd course	29	0.37	1.00
Max melphalan	Max melphalan <5mg vs >= 5mg during 2nd course	29	0.86	0.49
Max melphalan/Kg	Max melphalan/Kg <0.4mg/Kg vs >=0.4mg/Kg during 2nd course	29	0.43	0.66
Cumltv melphalan	Cumltv melphalan <8mg vs >= 8mg during 2nd course	29	0.56	0.21
Cumltv melphalan/Kg	Cumltv melphalan/Kg <0.6mg/Kg vs >= 0.6mg/Kg during 2nd course	29	0.83	0.50
Increasing max melphalan	Increasing vs decreasing max melphalan during 2nd course	28	0.88	0.63
Increasing max melphalan/Kg	Increasing vs decreasing max melphalan/Kg during 2nd course	28	0.22	0.13
Increasing max topotecan/Kg	Increasing vs decreasing max topotecan/Kg during 2nd course	20	0.04	0.28
Increasing max carboplatin/Kg	Increasing vs decreasing max carboplatin/Kg during 2nd course	12	0.42	1.00
Increasing max dose any drug	Increasing vs decreasing max dose any drug during 2nd course	29	0.67	0.75
Increasing max dose/Kg any drug	Increasing vs decreasing max dose/Kg any drug during 2nd course	29	0.07	0.75
Increasing cumltv melphalan	Increasing vs decreasing cumltv melphalan during 2nd course	29	0.85	0.40
Increasing cumltv melphalan/Kg	Increasing vs decreasing cumltv melphalan/Kg during 2nd course	29	0.39	0.83
Increasing cumltv topotecan/Kg	Increasing vs decreasing cumltv topotecan/Kg during 2nd course	19	0.09	0.25
Increasing cumltv carboplatin/Kg	Increasing vs decreasing cumltv carboplatin/Kg during 2nd course	12	0.99	1.00
Increasing cumltv any drug	Increasing vs decreasing cumltv dose any drug during 2nd course	29	0.86	0.45
Increasing cumtv dose/Kg any drug	Increasing vs decreasing cumtv dose/Kg any drug during 2nd course	29	0.14	0.62
Increasing max dose/Kg any drug/new drug	Increasing max dose/Kg any drug or new drug vs. not during 2nd course	29	0.24	0.79

PFS= progression free survival, OS = ocular survival, cumtv= cumulative, max= maximum, OAC = ophthalmic artery chemosurgery, yr = year, no. = number, vs = versus, cumltv = cumulative, btwn = between, mos= months