Figure 4.

Latency to correct response (a) was higher in NK1R–/– mice than in wild types. The highest dose of methylphenidate (MPH30) increased this measure in wild types only. Methylphenidate reduced the latency to collect the reward (b), especially in NK1R-/- mice, but only the intermediate dose affected both genotypes. The intermediate and highest dose of methylphenidate increased the latency to false alarms (c) for wild types only. Bars show mean±SEM score for the five test conditions. White bars: wild types; shaded bars: NK1R-/- mice; NI-2: no-injection (results for NI-1 are reported in Porter et al., 2016); VEH: vehicle; MPH3, MPH10 and MPH30: methylphenidate 3, 10 and 30 mg/kg, respectively. Lines linking pairs of data indicate a statistically significant difference between the two genoptypes at p<0.05 at least. *p<0.05, by comparison with vehicle injection test condition. Details of exact p-values are given in the text. N=11 or 12 per group.