Table 2.
Overview of data on spontaneous abortions. NA: Not applicable because of no control/unvaccinated group. RR: Relative risk (HPV over Control). 95% CI: exact 95% confidence interval for relative risk.
| Authors | Coutry / Year | Vaccine | Sp. abortions in pregnancies included in analysis, HPV No. (%) | Sp.abortions in pregnancies included in analysis, HAV No. (%) | Sp. abortions in pregnancies included in analysis, placebo No.(%) | P value / RR |
|---|---|---|---|---|---|---|
| Wacholder et al.16 | Costa Rica / 2010 | Cervarix™ | 197/1708 (11.5%) | 176/1727 (10.2%) | NA | P = 0.16 |
| Panagiotou et al.17 | Costa Rica / 2015 | Cervarix™ | 451/3394 (13.3%) | *316/2507 (12.6%) | **98/720 (13.6%) | *RR 1.05 (0.91–1.21) **RR 0.95 (0.77–1.18) |
| Garland et al.18 | Australia /2009 | Gardasil® | 366/2008 (18.2%) | 395/2029 (19.5%) | NA | P = 0.96 |
| Dana et al.19 | USA / 2009 | Gardasil® | 34/517 (6.6%) | NA | NA | NA |
| Angelo et al.20 | Belgium/USA / 2014 | Cervarix™ | 71/465 (15.3%) | NA | 50/449 (11.1%) | RR 1.37 (95% CI 0.94–2.01) |