Table 1.
Comparison of visual outcomes between NMOSD–ON eyes with AQP4-IgG and MOG-IgG and age-matched MS–ON eyes.
| AQP4+ NMOSD–ON eyes [1] |
MS–ON eyes [2] |
p value [1–2] |
MOG+ NMOSD–ON eyes [3] |
MS–ON eyes [4] |
p value [3–4] |
|
|---|---|---|---|---|---|---|
| Sex n [%] (female) | 6 [66%] | 7 [77%] | 0.910 | 3 [50%] | 2 [33%] | 0.558 |
| Age (years) | 34.9 [19.4–43.8] | 32.6 [27.6–36.7] | 0.965 | 54.4 [53.4–58.1] | 49.7 [42.2–61.5] | 0.240 |
| Number of ON | 2 [1–3.5] | 2 [1–2] | 0.352 | 1.5 [1–4] | 2 [1–2.25] | 0.932 |
| Time since last ON (months) | 86.4 [15.2–107.3] | 28.1 [14.1–100.2] | 0.436 | 99.0 [21.4–185.8] | 139.1 [69.1–169.6] | 0.485 |
| HCVA (#0-70 letters) | 45 [28–64] | 58 [50–60] | 0.565 | 47 [40–56] | 55 [41–56] | 0.310 |
| 2.5% LCVA (#0-70 letters) | 0 [0–20] | 21 [3–30] | 0.159 | 13 [0–30] | 27 [0–30] | 0.662 |
| 1.25% LCVA (#0-70 letters) | 0 [0–0] | 4 [0–20] | 0.031 | 0 [0–6] | 10 [0–18] | 0.247 |
| HRR (#0-36 symbols) | 21 [6–36] | 36 [29–36] | 0.052 | 35 [17–36] | 31 [12–35] | 0.329 |
| Visual field (MD) (dB) | −5.9 [−12.5 to −0.5] | −4.3 [−6.5 to −2.2] | 0.831 | −2.7 [−4.7 to −1.9] | −2.5 [−6.6 to −1.7] | 0.841 |
| pRNFL thickness (µm) | 50 [40–77] | 80 [72–90] | 0.038 | 68 [48–78] | 74 [65–78] | 0.310 |
| mGCC thickness (µm) | 67 [62–100] | 91 [78–99] | 0.112 | 82 [62–93] | 83 [65–92] | 0.872 |
| INL thickness (µm) | 43 [42–46] | 39 [37–42] | 0.021 | 40 [37–41] | 40 [40–42] | 0.565 |
| OPL thickness (µm) | 30 [29–33] | 35 [32–38] | 0.008 | 30 [28–37] | 32 [30–36] | 0.626 |
| ONL thickness (µm) | 80 [78–81] | 71 [65–75] | 0.021 | 75 [68–80] | 76 [71–81] | 0.872 |
| PR thickness (µm) | 80 [78–81] | 82 [80–84] | 0.190 | 81 [77–83] | 82 [80–86] | 0.416 |
Data represents median [P25–P75] unless otherwise indicated. Chi-squared Pearson test for categorical variables and Mann–Whitney U test for quantitative variables.
AQP4+: antibodies against Aquaporin 4; HCVA: high contrast visual acuity; HRR: Hardy, Rand and Rittler pseudoisochromatic plates; INL: macular inner nuclear layer; LCVA: low contrast visual acuity; MD: mean deviation; mGCC: macular ganglion cell complex; MOG+: antibodies against myelin oligodendrocyte glycoprotein; MS: multiple sclerosis; NMOSD: neuromyelitis optica spectrum disorder; OCT: optical coherence tomography; ON: optic neuritis; ONL; macular outer nuclear layer; OPL: macular outer plexiform layer; PR: photoreceptors including retinal pigment epithelium and Bruch membrane; pRNFL: peripapillary retinal nerve fibre layer.