Table 1.

Canadian Network for Mood and Anxiety Treatments (CANMAT) Criteria for Level of Evidence.

Level of Evidencea	Criteria
1	Meta-analysis with narrow confidence intervals and/or 2 or more randomized controlled trials (RCTs) with adequate sample size, preferably placebo controlled
2	Meta-analysis with wide confidence intervals and/or 1 or more RCTs with adequate sample size
3	Small-sample RCTs or nonrandomized, controlled prospective studies or case series or high-quality retrospective studies
4	Expert opinion/consensus

^aNote that Level 1 and 2 Evidence refers specifically to treatment studies in which randomized comparisons are available. Recommendations involving epidemiological or risk factors primarily arise from observational studies, and hence the highest level of evidence is usually Level 3. Higher order recommendations (e.g., principles of care) reflect higher level judgment of the strength of evidence from various data sources and therefore are primarily Level 4 Evidence.