. 2016 Aug 2;61(9):506–509. doi: 10.1177/0706743716659061

Table 2.

Canadian Network for Mood and Anxiety Treatments (CANMAT) Criteria for Line of Treatment.

Line of Treatment	Criteria
First line	Level 1 or Level 2 Evidence, plus clinical support^a
Second line	Level 3 Evidence or higher, plus clinical support^a
Third line	Level 4 Evidence or higher, plus clinical support^a

^aClinical support refers to application of expert opinion of the CANMAT committees to ensure that evidence-supported interventions are feasible and relevant to clinical practice. Therefore, treatments with higher levels of evidence may be downgraded to lower lines of treatment due to clinical issues such as side effects or safety profile.