Table 1.
Mean changes in blood pressure, fasting lipid parameters, and weight with vildagliptin at week 24
| Parameters | Vildagliptin qd/bid n=2,108
|
Mean change | P-value | |
|---|---|---|---|---|
| Baseline value | Endpoint value | |||
| BP parameters, mean ± SE | ||||
| Systolic BP, mmHg | 132.5±0.32 | 129.8±0.34 | −2.70±0.30 | <0.0001 |
| Diastolic BP, mmHg | 81.2±0.18 | 79.6±0.19 | −1.64±0.18 | <0.0001 |
| Fasting lipid parameters, mean ± SE | ||||
| Fasting triglycerides (mmol/L) | 2.00±0.02 | 1.80±0.02 | −0.20±0.02 | <0.0001 |
| VLDL (mmol/L) | 0.90±0.01 | 0.83±0.01 | −0.07±0.01 | <0.0001 |
| LDL (mmol/L) | 3.17±0.02 | 3.04±0.02 | −0.13±0.02 | <0.0001 |
| Total cholesterol (mmol/L) | 5.26±0.02 | 5.08±0.02 | −0.18±0.02 | <0.0001 |
| Non-HDL (mmol/L) | 4.07±0.02 | 3.87±0.02 | −0.21±0.02 | <0.0001 |
| HDL (mmol/L) | 1.19±0.01 | 1.22±0.01 | 0.03±0.004 | <0.001 |
| Body weight (mean ± SE, kg) | 86.16±0.41 | 85.67±0.40 | −0.48±0.08 | <0.001 |
Abbreviations: BP, blood pressure; bid, twice daily; HDL, high density lipoprotein; LDL, low density lipoprotein; qd, once daily; SE, standard error; VLDL, very low density lipoprotein.