Table 3.
Top 15 up- regulated genes in the bed of non-healing ulcers compared to the bed of healing ulcers.
| Affymetrix Probe Set ID |
P- Value |
Raw Fold Change |
Gene Descriptor | Unigene ID | Gene Symbol |
Sequence Derived From |
Function | Disease association | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 202357_s_at | 0.0007 | 8.41 | B-factor, properdin | Hs.69771 | BF | NM_001710.1 | Peptidase, a component of the alternative pathway of complement activation | Rheumatoid arthritis, atherosclerosis |
| 2 | 213071_at | 0.0319 | 7.77 | Dermatopontin | Hs.80552 | DPT | AL049798 | ECM protein with possible functions in cell-matrix interactions and matrix assembly. | Myocardial infarction, keloids |
| 3 | 229947_at | 0.0362 | 4.85 | Peptidase inhibitor 15 | Hs.98558 | PI15 | AI088609 | Peptidase, trypsin inhibitor | Glyoblastoma and neruoblastoma |
| 4 | 202437_s_at | 0.0401 | 4.63 | Cytochrome P450, family 1, subfamily B, polypeptide 1 | Hs.154654 | CYP1B1 | NM_000104.2 | Steroidogenesis | Breast, colon, lung, esophagus, skin, lymph node, brain, and testis cancer, congenital glaucoma |
| 5 | 202075_s_at | 0.0232 | 4.21 | Phospholipid transfer protein | Hs.439312 | PLTP | NM_006227.1 | Cholesterol metabolism | Atherosclerosis,hypertrigly ceridemia,insulin resistance |
| 6 | 224840_at | 0.0073 | 4.03 | FK506 binding protein 5 | Hs.7557 | FKBP5 | AI753747 | Role in immunoregulation, binds steroid receptors in complex with Hsp 90 and Hsp70 | Glucocorticoid resistance; prostate cancer; idiopathic myelofibrosis |
| 7 | 202994_s_at | 0.0474 | 3.50 | Fibulin 1 | Hs.445240 | FBLN1 | Z95331 | Cell adhesion and migration along protein fibers within the extracellular matrix (ECM); ECM architecture | Breast and ovarian cancer |
| 8 | 201108_s_at | 0.0118 | 3.39 | Thrombospondin 1 | Hs.164226 | THBS1 | BF055462 | Cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin, type v collagen and integrins alpha-v/beta-1, alpha- v/beta-3 and alpha-iib/beta-3 | Wound healing, skin cancers, breast cancer |
| 9 | 203131_at | 0.0216 | 3.36 | Platelet-derived growth factor receptor, alpha polypeptide | Hs.74615 | PDGFRA | NM_006206.1 | Receptor that binds both pdgfa and pdgfb and has a tyrosine-protein kinase activity; mitogen for cells of mesenchymal origin | Some cases of hypereosinophilic syndrome (hes) |
| 10 | 229390_at | 0.0443 | 3.28 | Family with sequence similarity 26, member F | Hs.381220 | FAM26F | AV734646 | Unknown | Unknown |
| 11 | 207761_s_at | 0.0152 | 3.14 | DKFZP586A0522 protein; synonyms: AAM B, UbiE | Hs.288771 | DKFZP586A0522 | NM_014033 | Methyltransferase like 7A; gene expression | Unknown |
| 12 | 1558881_at | 0.0053 | 3.13 | Hypothetical protein LOC145820 | Hs.171000 | LOC145820 | AK057337 | Unknown | Unknown |
| 13 | 227525_at | 0.0069 | 3.11 | Glucocorticoid induced transcript 1 | Hs.435806 | GLCCI1 | AA058770 | Unknown | Unknown |
| 14 | 219869_s_at | 0.0452 | 2.95 | Solute carrier family 39 (zinc transporter), member 8 | Hs.284205 | BIGM103 | NM_022154 | Involved in protein, nucleic acid, carbohydrate, and lipid metabolism, control of gene transcription, growth, development, and differentiation | Bladder cancer |
| 15 | 204900_x_at | 0.0345 | 2.73 | Sin3-associated polypeptide, 30kDa | Hs.413835 | SAP30 | NM_003864 | Active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones | Melanoma |