Table 4.
Top 15 down- regulated genes in the bed of non-healing ulcers compared to the bed of healing ulcers.
| Affymetrix Probe Set ID | P-Value | Raw Fold Change | Gene Descriptor | Unigene ID | Gene Symbol | Sequence Derived From | Function | Disease association | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 205656_at | 0.0181 | −3.67 | Protocadherin 17 | Hs.106511 | PCDH17 | NM_014459.1 | Cell- cell connections | Retinoblastoma |
| 2 | 207134_x_at | 0.0144 | −3.45 | Tryptase beta 2 | Hs.405479 | TPSB2 | NM_024164 | Major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type | Asthma, allergic and inflammatory disorders |
| 3 | 201490_s_at | 0.0214 | −3.45 | Peptidylprolyl isomerase F (cyclophilin F) | Hs.381072 | PPIF | NM_005729 | Apoptosis and necrotic cell death; accelerates the folding of proteins | Myodegenerative disorders |
| 4 | 222688_at | 0.0100 | −3.15 | Phytoceramidase, alkaline | Hs.23862 | PHCA | R12678 | Ceramide metabolism | Unknown |
| 5 | 201996_s_at | 0.0439 | −3.03 | SMART/HDAC1 associated repressor protein | Hs.184245 | SHARP | AL524033 | Unknown | Unknown |
| 6 | 213478_at | 0.0368 | −2.75 | Kazrin | Hs.368823 | KIAA1026 | AB028949 | Cell-cell conectins | Unknown |
| 7 | 205178_s_at | 0.0449 | −2.57 | Retinoblastoma binding protein 6 | Hs.188553 | RBBP6 | NM_006910.1 | Suppression of cellular proliferation | Inactivated in various cancers |
| 8 | 41644_at | 0.0398 | −2.49 | SAM and SH3 domain containing 1 | Hs.166311 | SASH1 | 4862579_RC | May have a role in a signaling pathway; could act as a tumor suppressor. | Breast tumor, colon cancer |
| 9 | 212611_at | 0.0229 | −2.48 | Macrophage expressed gene 1 | Hs.62264 | MPEG1 | AV728526 | Unknown | Fibrosis |
| 10 | 221992_at | 0.0138 | −2.42 | Similar to nuclear pore complex interacting protein | Hs.448833 | Unknown | AI925734 | Unknown | Unknown |
| 11 | 38037_at | 0.0240 | −2.40 | Heparin-binding epidermal growth factor-like growth factor | Hs.799 | HBEGF | M60278 | Cellular proliferation; mitogenic for fibroblasts and smooth muscle but not endothelial cells; binds egf receptors | Epithelial tumors, acute myeloid and acute lymphoid leukemia |
| 12 | 206491_s_at | 0.0001 | −2.35 | N-ethylmaleimide-sensitive factor attachment protein, alpha | Hs.75932 | NAPA | NM_003827.1 | Vesicular transport between the endoplasmic reticulum and the golgi apparatus | Huntington's disease |
| 13 | 224940_s_at | 0.0432 | −2.30 | A specific BCL2 ARE-binding protein 2 | Hs.440769 | ASBABP2 | BF107618 | Unknown | Unknown |
| 14 | 230167_at | 0.0087 | −2.27 | A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 14 | Hs.352156 | ADAMTS14 | W60649 | Collagen catabolism | Dupuytren's disease, Ehlers-Danlos syndrome dermatosparactic type or VIIC |
| 15 | 231960_at | 0.0123 | −2.26 | WD repeat domain 9 | Hs.435904 | WDR9 | AA807344 | Chromatin remodeling | Unknown |