Table 2.

Clinical Characteristics of Different Detectable Serum anti-TNFα Drug Levels

	Low Level (n=6)	Medium Level (n=17)	High Level (n= 44)	p
Mean Age (years)	32.2 (19.2)	40.1 (17.1)	37.1 (16.3)	0.60
Gender M:F	3 : 3	13 : 4	29 : 15	0.46
Type of IBD
Crohn’s disease	3 (50)	12 (71)	35 (79)	0.23
Ulcerative colitis	3 (50)	5 (29)	9 (21)
Preoperative Steroids	3 (50)	12 (70)	32 (73)	0.58
Preoperative Immunomodulators
6-mercaptopurine	5 (83)	9 (53)	33 (75)	0.23
Azathioprine	0	1 (6)	1 (2)	0.57
Methotrexate	1 (17)	1 (6)	7 (16)	0.53
Cyclosporine	2 (33)	1 (6)	3 (7)	0.12
Preoperative anti-TNFα Agent
Infliximab alone	5 (83)	10 (59)	21 (48)	0.27
Adalimumab alone	1 (17)	5 (29)	3 (7)	0.06
Certolizumab alone	0	1 (6)	1 (2)	0.57
Multiple	0	1 (6)	19 (43)	0.003
Mean Preoperative Lab Values
Hemoglobin (g/dl)	10.7 (0.97)	10.9 (1.98)	12.7 (1.75)	0.004
Serum albumin (g/dl)	3.6 (0.34)	3.42 (0.73)	4.0 (0.62)	0.03
C-reactive protein (mg/dl)	5.72 (2.03)	2.94 (4.03)	1.76 (2.91)	0.05
Indication for Surgery
Medical intractability	6 (100)	15 (88)	38 (86)	1.0
Abscess at time of surgery	0	1 (6)	6 (14)	0.83
Dysplasia/cancer	0	1 (6)	0	0.34
Surgical Procedures
Small bowel/ ileocolic resection	3 (50)	12 (71)	30 (68)	0.62
Ileal pouch-anal anastomosis	2 (33)	2 (12)	3 (7)	0.10
Subtotal colectomy and ileostomy	1 (17)	4 (24)	6 (14)	0.67
Low colorectal anastomosis	0	1 (6)	5 (11)	1.0
Closure of ileostomy/colostomy	0	0	0	-
Total proctocolectomy/ileostomy	0	0	0	-
Pelvic Anastomosis Created	2 (33)	3 (18)	8 (18)	0.71

All values in parentheses denote % except age and preoperative lab values (standard deviation)

IBD inflammatory bowel disease