Table 3.

UC Patient Cohort Clinical Characteristics and Serum anti-TNFα Drug Levels

	UC Cohort (n = 94)	Undetectable Level (n = 77)	Detectable Level (n =17)	p
Mean Age (years)	38.4 (15.9)	37.2 (14.38)	43.8 (21.52)	0.12
Gender M: F	45 : 49	34 : 43	11 : 6	0.59
Indication for Surgery
Medical Intractability	81 (86)	67 (87)	14 (82)	0.13
Dysplasia/Cancer	13 (14)	10 (13)	3 (18)
Type of Surgery
3-Stage (STC as index operation)	42 (45)	32 (41)	10 (59)	0.20
2-Stage (IPAA as index operation)	52 (55)	45 (59)	7 (41)
Mean Preoperative lab values
Hemoglobin (g/dl)	11.6 (1.7)	11.6 (1.8)	11.6 (1.6)	0.90
Serum albumin (g/dl)	3.7 (0.7)	3.7 (0.7)	3.5 (0.7)	0.75
C-reactive protein (mg/dl)	2.0 (3.9)	2.2 (4.2)	1.0 (2.4)	0.42
Preoperative Steroids	17 (18)	13 (17)	4 (24)	0.50
Preoperative Immunomodulators
6-mercaptopurine	31 (33)	27 (35)	4 (23)	0.41
Azathiopurine	3 (3)	3 (4)	0	1.00
Methotrexate	6(6)	6 (8)	0	0.59
Cyclosporine	25 (26)	19 (25)	6 (35)	0.38
Preoperative anti-TNFα agent	60 (64)	43 (56)	17 (100)	0.02

All values in parentheses denote % except preoperative lab values (standard deviation)

UC ulcerative colitis; STC subtotal colectomy; IPAA ileal pouch-anal anastomosis