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. Author manuscript; available in PMC: 2016 Dec 23.
Published in final edited form as: Nat Immunol. 2016 Jun 23;17(9):1102–1108. doi: 10.1038/ni.3515

Figure 4. Anti- DENV human monoclonal antibodies bind to ZIKV.

Figure 4

(a) Binding of ZIKV strains PF13 and HD78788 and DENV serotype 1 by 33, 17, 45, 37 of anti-EDE1, EDE2, FLE and non-FLE mAbs at 10 μg/ml, also included are 12 mAbs termed IB-3, IB-4 and IB-5 which were poorly neutralizing but reacted to a conformational epitope that was lost when envelope protein was denatured by immunoblotting. These data are representative of three separate experiments. The arrows indicate mAbs used in Fig. 4b, 5, and 6. (b) Binding titration curves for 9 representative mAbs (3 each for anti-EDE1, EDE2, and FLE mAbs). The data shows mean±SEM from 3 independent experiments.