Figure 6. Anti-EDE1 human monoclonal antibodies inhibit ADE of DENV plasma.
The inhibition curves of 9 anti-DENV mAbs (3 each for anti-EDE1, EDE2, and FLE mAbs) on ZIKV strains PF13 and HD78788 (fold increase in FFU). U937 cells were infected with ZIKV in the presence of 1:10,000 PCS (the dilution giving peak enhancement) together with serially diluted anti-DENV mAbs. Anti-flu mAb, 28C, was used as a negative control. The data are shown as mean±SEM from 3 independent experiments.