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. Author manuscript; available in PMC: 2016 Aug 23.

Published in final edited form as: Clin Cancer Res. 2011 Feb 24;17(10):3398–3407. doi: 10.1158/1078-0432.CCR-10-1969

(A) LVEF data for all study patients over time (N = 80). (B) LVEF data for the seven patients (9%) who experienced a symptomatic LVEF decline or an asymptomatic LVEF decline necessitating bevacizumab hold/discontinuation. Patient 1: Month-15 symptomatic LV dysfunction, cardiac catheterization and left anterior descending stenting; Patient 2: Month-2 bevacizumab hold and subsequent consent withdrawal despite LVEF recovery; Patient 3: Month-6 apical hypokinesis (LVEF, 53%) and subsequent study withdrawal; Patients 4 and 5: Asymptomatic LVEF decline with subsequent recovery post bevacizumab discontinuation; Patients 6 and 7: Month-3 and month-9 bevacizumab hold with subsequent reinstitution.

(A) LVEF data for all study patients over time (N = 80). (B) LVEF data for the seven patients (9%) who experienced a symptomatic LVEF decline or an asymptomatic LVEF decline necessitating bevacizumab hold/discontinuation. Patient 1: Month-15 symptomatic LV dysfunction, cardiac catheterization and left anterior descending stenting; Patient 2: Month-2 bevacizumab hold and subsequent consent withdrawal despite LVEF recovery; Patient 3: Month-6 apical hypokinesis (LVEF, 53%) and subsequent study withdrawal; Patients 4 and 5: Asymptomatic LVEF decline with subsequent recovery post bevacizumab discontinuation; Patients 6 and 7: Month-3 and month-9 bevacizumab hold with subsequent reinstitution.