Table 2.
Patient characteristics (N = 80).
| Characteristics | No. | % |
|---|---|---|
| Age, years | ||
| Median | 48 | |
| Range | 27−75 | |
| < 40 | 15 | 19 |
| 40–49 | 30 | 38 |
| 50–59 | 24 | 30 |
| 60–69 | 10 | 13 |
| ≥ 70 | 1 | 1 |
| Tumor size, cm | ||
| ≤ 2.0 | 21 | 26 |
| 2.1–5.0 | 52 | 65 |
| > 5.0 | 7 | 9 |
| Node status | ||
| 0 | 8 | 10 |
| 1–3 | 35 | 44 |
| 4–9 | 20 | 25 |
| > 9 | 17 | 21 |
| Stage* | ||
| I | 2 | 3 |
| IIA | 18 | 23 |
| IIB | 21 | 26 |
| IIIA | 23 | 29 |
| IIIB | 16 | 20 |
| Estrogen receptor status | ||
| Positive | 58 | 73 |
| Negative | 22 | 28 |
| Progesterone receptor status | ||
| Positive | 51 | 64 |
| Negative | 29 | 36 |
| ECOG performance status | ||
| 0 | 67 | 84 |
| 1 | 13 | 16 |
| Surgery | ||
| Resection of ipsilateral recurrence with axillary dissection and adjuvant XRT |
1 | 1 |
| Breast-conserving surgery | 23 | 29 |
| With adjuvant XRT | 21 | 26 |
| With subsequent mastectomy | 1 | 1 |
| Other (diagnosed with metastases post cycle 1) | 1 | 1 |
| Mastectomy | 56 | 70 |
| Without reconstruction | 16 | 20 |
| Immediate prestudy tissue expander | 39 | 49 |
| Tissue expander exchange on study | 12 | 15 |
| Tissue expander exchange post study | 15 | 19 |
| Tissue expander exchange off study | 8 | 10 |
| Failed tissue expansion | 3 | 4 |
| No exchange because of disease progression | 1 | 1 |
| Delayed TRAM | 1 | 1 |
| Post mastectomy XRT | 35 | 44 |
| Median baseline LVEF, % (range) | 68 (53–82) | |
*
According to the American Joint Committee on Cancer Staging Manual, 6th ed.
Abbreviations: XRT, radiation therapy; TRAM, transverse rectus abdominis musculocutaneous.