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Selinexor induces death signaling in primary AML cells. Bone marrow cells from AML xenografts were exposed ex vivo to 100 nM KPT-330 for 16 h and then Dynamic BH3 profiling was performed. Selinexor induced an increase in mitochondrial priming (Δ% priming) in AML-CN and AML-CK1 but not AML-CK2.
