Figure 2.

Effects of doxorubicin (DOX) with/without sitagliptin pretreatment on heart histology of rats. (a) Control group: normal heart architecture was observed, (b) DOX group showed disruption of cardiac muscle architecture, loss of muscle striation, hydropic degeneration, apoptosis, and focal necrosis. Cardiac myocytes show focal apoptosis and signs of necrosis (pyknosis, kariorrhexis and karyolysis) with inflammatory cellular infiltrate (c, d) Sitagliptin + DOX groups; improvement of the cardiac lesions. Hematoxylin and eosin stain. Original magnification ×200. (A color version of this figure is available in the online journal.)