Table 2.

Histopathological semi-quantitative scoring showing the effects of doxorubicin (DOX) with/without sitagliptin (Sita) pretreatment on severity of histopathologic lesions in DOX-treated rats

Histopathological changes	Control	DOX	Sitagliptin (10 mg/kg) + DOX	Sitagliptin (20 mg/kg) + DOX
Disruption of cardiac muscles architecture	−	+ ++	++	+
Loss of muscular striations	−	+++	++	+
Vascular congestion	−	+++	+	±
Interstitial hemorrhage and hemosiderin deposition	−	+++	±	−
Cloudy swelling and hydropic degeneration	−	+++	+	+
Fatty degeneration	−	+	−	−
Inflammatory cellular infiltrate	−	++	+	±
Apoptosis	−	++	+	+
Necrosis (nuclear pyknosis, karyorrhexis, karyolysis)	−	+++	+	−

Note: Scores represent values obtained from tissue sections of six animals of each group, 5 fields/section (×40). Scores –, normal; ± borderline; + mild; ++, moderate; +++, severe levels.