Figure 3.

Repeated administration of antidepressant drugs affects active contact sensitivity in mice. On the second day of treatment with each respective antidepressant drug mice were contact sensitized with picryl chloride (PCL), and five days later were challenged by topical application of PCL on the skin of both ears. Elicited contact sensitivity reaction was measured (a) 2 h and (b) 24 h later as ear swelling response and, after subtraction of ear thickness increase in non-sensitized but challenged littermate animals, expressed as delta ± standard error (SE). N = 5; *P < 0.05; **P < 0.01; ***P < 0.005