Figure 4.

Hapten-conjugated macrophages from antidepressant drug-treated donors influence the contact sensitivity reaction in sensitized recipients. Oil-induced peritoneal macrophages from mice treated for seven days with respective antidepressant drug were conjugated with trinitrophenyl (TNP) hapten and then transferred intravenously into naive recipients that on the next day were sensitized with picryl chloride (PCL). Five days later, recipients of TNP-conjugated macrophages were challenged with PCL on the skin of both ears. Contact sensitivity reaction was measured (a) 2 h and (b) 24 h later as ear swelling response and, after subtraction of ear thickness increase in non-sensitized but challenged littermate animals, expressed as delta ± standard error (SE). N = 5; *P < 0.05; **P < 0.01