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The negative regulation of Wnt-β-catenin by OSX is in part through activation of DKK1. A – Wnt-β-catenin is able to stimulate PDL or DF proliferation and inhibit cementoblast differentiation. B – OSX negatively regulates Wnt-β-catenin through activating DKK1 – a potent inhibitor of Wnt signaling. PDL – periodontal ligament. DF – dental follicles.
